Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 7/20 | 0.32 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.31 |
| ▸ | CKS1B | P61024 | 1/20 | 0.31 |
| ▸ | SKP1 | P63208 | 1/20 | 0.31 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12064983 | 0.92 | GPR119 (0.36) | NR1H2GRM4LMNAMAPT | |
| SCHEMBL12064814 | 0.92 | NR1H2 (0.33) | NR1H2GRM4RETEIF2AK4CKS1B | |
| SCHEMBL470535 | 0.91 | NR1H2 (0.33) | NR1H2GRM4RETEIF2AK4CKS1B | |
| SCHEMBL463066 | 0.91 | NR1H2 (0.33) | NR1H2GRM4RETEIF2AK4CKS1B | |
| SCHEMBL470486 | 0.90 | NTRK1 (0.36) | NR1H2RETACACB | |
| SCHEMBL14730175 | 0.86 | SYK (0.32) | NR1H2RETEIF2AK4CKS1BSKP1 | |
| SCHEMBL470523 | 0.86 | NTRK1 (0.35) | NR1H2RETEIF2AK4CKS1BSKP1 | |
| SCHEMBL462819 | 0.86 | NTRK1 (0.34) | NR1H2RETOPRK1 | |
| SCHEMBL12064744 | 0.85 | NTRK1 (0.34) | NR1H2RET | |
| SCHEMBL145107 | 0.84 | DPP4 (0.32) | NR1H2RETEIF2AK4ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |