Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 18/20 | 0.50 |
| ▸ | GPR183 | P32249 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL461134 | 0.89 | GPR119 (0.50) | GPR119GPR183ABCB1ABCC1ABCG2 | |
| SCHEMBL470560 | 0.80 | GPR119 (0.55) | GPR119GPR183ABCB1ABCC1ABCG2 | |
| SCHEMBL19434281 | 0.77 | GPR119 (0.55) | GPR119GPR183ABCB1ABCC1ABCG2 | |
| SCHEMBL470450 | 0.77 | GPR119 (0.54) | GPR119GPR183ABCB1ABCC1ABCG2 | |
| SCHEMBL12064532 | 0.76 | GPR119 (0.66) | GPR119GPR183ABCB1ABCC1ABCG2 | |
| SCHEMBL470859 | 0.75 | GPR119 (0.40) | GPR119GPR183ABCB1ABCC1ABCG2 | |
| SCHEMBL461135 | 0.74 | GPR119 (0.61) | GPR119GPR183ABCB1ABCC1ABCG2 | |
| SCHEMBL12064533 | 0.74 | GPR119 (0.53) | GPR119GPR183ABCB1ABCC1ABCG2 | |
| SCHEMBL18843833 | 0.74 | GPR119 (0.63) | GPR119GPR183ABCB1ABCC1ABCG2 | |
| SCHEMBL21665285 | 0.73 | GPR119 (0.62) | GPR119GPR183ABCB1ABCC1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |