Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 17/20 | 0.55 |
| ▸ | GPR183 | P32249 | 1/20 | 0.54 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL461992 | 0.88 | GPR119 (0.55) | GPR119GPR183CNR2ACACBABCB1 | |
| SCHEMBL470450 | 0.86 | GPR119 (0.54) | GPR119GPR183CNR2ABCB1ABCC1 | |
| SCHEMBL11956900 | 0.86 | GPR119 (0.54) | GPR119GPR183CNR2ACACB | |
| SCHEMBL470623 | 0.84 | GPR119 (0.53) | GPR119GPR183CNR2 | |
| SCHEMBL13186690 | 0.84 | GPR119 (0.46) | GPR119GPR183CNR2KCNH2 | |
| SCHEMBL11978475 | 0.84 | GPR119 (0.52) | GPR119GPR183CNR2ACACB | |
| SCHEMBL461663 | 0.82 | GPR119 (0.54) | GPR119GPR183CNR2ABCB1ABCC1 | |
| SCHEMBL12064532 | 0.81 | GPR119 (0.66) | GPR119GPR183CNR2ABCB1ABCC1 | |
| SCHEMBL1092906 | 0.81 | GPR119 (0.58) | GPR119GPR183ACACBKCNH2 | |
| SCHEMBL470642 | 0.80 | GPR119 (0.50) | GPR119GPR183CNR2ABCB1ABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |