Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 16/20 | 0.51 |
| ▸ | CDK2AP1 | O14519 | 6/20 | 0.51 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703475 | 0.95 | CHEK1 (0.53) | CHEK1CDK2AP1 | |
| SCHEMBL4213212 | 0.90 | CHEK1 (0.52) | CHEK1CDK2AP1 | |
| SCHEMBL4706732 | 0.87 | CHEK1 (0.66) | CHEK1CDK2AP1 | |
| SCHEMBL4702663 | 0.87 | CHEK1 (0.66) | CHEK1CDK2AP1 | |
| SCHEMBL4702760 | 0.87 | CHEK1 (0.66) | CHEK1CDK2AP1 | |
| SCHEMBL4702699 | 0.87 | CHEK1 (0.54) | CHEK1CDK2AP1HRH2HRH1KDM4E | |
| SCHEMBL4211957 | 0.85 | CHEK1 (0.54) | CHEK1CDK2AP1 | |
| SCHEMBL4706488 | 0.83 | CHEK1 (0.56) | CHEK1CDK2AP1 | |
| Trifluoroacetic Acid SCHEMBL4223931 | 0.83 | CHEK1 (0.51) | CHEK1CDK2AP1 | |
| SCHEMBL4706268 | 0.82 | CHEK1 (0.68) | CHEK1CDK2AP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660474-B1 | SUBSTITUTED THIOPHENES AND USES THEREOF | ASTRAZENECA AB (SE) | 2008-10-29 | — | — | EP | claimed |