Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | REN | P00797 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5766456 | 0.91 | LMNA (0.54) | GAADRD2LMNAMEN1TSHR | |
| SCHEMBL30606607 | 0.88 | LMNA (0.44) | GAADRD2LMNAMEN1TSHR | |
| SCHEMBL26599167 | 0.88 | LMNA (0.44) | GAADRD2LMNAMEN1TSHR | |
| SCHEMBL29168148 | 0.85 | NQO2 (0.57) | GAADRD2LMNAMEN1TSHR | |
| SCHEMBL4708016 | 0.83 | MEN1 (0.52) | GAADRD2LMNAMEN1TSHR | |
| SCHEMBL13387818 | 0.81 | MALT1 (0.45) | DRD2LMNAMEN1TSHRKMT2A | |
| SCHEMBL5769723 | 0.81 | LMNA (0.54) | GAADRD2LMNAMEN1TSHR | |
| SCHEMBL4707006 | 0.80 | CHRM2 (0.49) | GAALMNAKMT2ANQO2HPGD | |
| SCHEMBL29761164 | 0.80 | CA12 (0.58) | TSHRNQO2CYP2D6MALT1BCHE | |
| SCHEMBL15586460 | 0.80 | NQO2 (0.57) | MEN1KMT2ANQO2HPGDATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501809-B1 | TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-01-16 | — | — | EP | disclosed |