Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NQO2 | P16083 | 1/20 | 0.49 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 4/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.41 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.41 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.41 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1820623 | 0.92 | LMNA (0.61) | LMNAMEN1KMT2ATSHRNQO2 | |
| SCHEMBL5766456 | 0.89 | LMNA (0.54) | LMNAMEN1KMT2ATSHRNQO2 | |
| SCHEMBL26598979 | 0.88 | NQO2 (0.48) | LMNAMEN1KMT2ATSHRNQO2 | |
| SCHEMBL4708016 | 0.82 | MEN1 (0.52) | LMNAMEN1KMT2ATSHRNQO2 | |
| SCHEMBL29168148 | 0.81 | NQO2 (0.57) | LMNAMEN1KMT2ATSHRNQO2 | |
| SCHEMBL8399561 | 0.81 | IDO1 (0.55) | MALT1TAAR1GAAIDO1BCHE | |
| SCHEMBL4706536 | 0.81 | GAA (0.51) | LMNAMEN1KMT2ATSHRNQO2 | |
| SCHEMBL26147436 | 0.80 | NPC1 (0.60) | LMNAMEN1KMT2ATSHRHPGD | |
| SCHEMBL4628833 | 0.79 | NQO2 (0.55) | LMNAMEN1KMT2ATSHRNQO2 | |
| SCHEMBL30606607 | 0.79 | LMNA (0.44) | LMNAMEN1KMT2ATSHRNQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638944-A1 | TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2005000821-A1 | TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-01-06 | — | — | WO | disclosed |