Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 14/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | OGA | O60502 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL384927 | 0.86 | HCRTR2 (0.41) | GPR119HCRTR1HCRTR2KDM4ENPC1 | |
| SCHEMBL470675 | 0.85 | GPR119 (0.48) | GPR119KDM4ENPC1RAB9AOGA | |
| SCHEMBL19450534 | 0.81 | GPR119 (0.45) | GPR119KCNH2HCRTR1HCRTR2OGA | |
| SCHEMBL19450805 | 0.81 | GPR119 (0.45) | GPR119KCNH2HCRTR1HCRTR2OGA | |
| SCHEMBL121345 | 0.80 | GPR119 (0.46) | GPR119KCNH2NR1H2NR1H3HCRTR1 | |
| SCHEMBL23525307 | 0.80 | GPR119 (0.53) | GPR119KCNH2NR1H2NR1H3HCRTR1 | |
| SCHEMBL19450757 | 0.79 | GPR119 (0.48) | GPR119KCNH2NR1H2NR1H3HCRTR1 | |
| SCHEMBL3647391 | 0.79 | GPR119 (0.55) | GPR119KCNH2HCRTR2SMO | |
| SCHEMBL21643105 | 0.78 | GPR119 (0.47) | GPR119KCNH2NR1H2NR1H3ACACB | |
| SCHEMBL19435019 | 0.77 | GPR119 (0.49) | GPR119KCNH2HCRTR1HCRTR2OGA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |