Sugi Predict

Sugi Predict / Compounds / SCHEMBL23525307

SCHEMBL23525307

SCHEMBL23525307

CC(C1CCN(c2ncc(Cl)cn2)CC1)S(=O)(=O)O

nearest known ligand 0.53

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 12/20 0.53
▸ KCNH2 Q12809 3/20 0.39
▸ HCRTR1 O43613 1/20 0.38
▸ HCRTR2 O43614 1/20 0.38
▸ NR1H2 P55055 1/20 0.37
▸ NR1H3 Q13133 1/20 0.37
▸ GRM2 Q14416 1/20 0.37
▸ GRM3 Q14832 1/20 0.37
▸ OGA O60502 1/20 0.37
▸ ACACB O00763 1/20 0.37
▸ MAPK8 P45983 1/20 0.36
▸ MAPK10 P53779 1/20 0.36
▸ SMO Q99835 1/20 0.35
▸ TIPARP Q7Z3E1 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL470546 0.84 GPR119 (0.49) GPR119KCNH2HCRTR1HCRTR2GRM2
SCHEMBL19434328 0.84 GPR119 (0.49) GPR119KCNH2HCRTR1HCRTR2GRM2
SCHEMBL19435019 0.84 GPR119 (0.49) GPR119KCNH2HCRTR1HCRTR2GRM2
SCHEMBL19450757 0.81 GPR119 (0.48) GPR119KCNH2HCRTR1HCRTR2NR1H2
SCHEMBL470679 0.80 GPR119 (0.52) GPR119KCNH2HCRTR1HCRTR2NR1H2
SCHEMBL22514061 0.78 GPR119 (0.46) GPR119KCNH2HCRTR1HCRTR2NR1H2
SCHEMBL121345 0.76 GPR119 (0.46) GPR119KCNH2HCRTR1HCRTR2NR1H2
SCHEMBL22514051 0.75 GPR119 (0.44) GPR119KCNH2HCRTR1HCRTR2NR1H2
SCHEMBL145832 0.75 GPR119 (0.41) GPR119KCNH2HCRTR1HCRTR2GRM2
SCHEMBL2891280 0.75 GPR119 (0.44) GPR119KCNH2HCRTR1HCRTR2GRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11358956-B2 Compounds containing polysubstituted benzo[d][1,3]oxathiole, benzo[d][1,3]oxathiole 3-oxide or benzo[d][1,3]oxathiole 3,3-dioxide and methods/uses thereof as agonists of G protein-coupled receptor 119 PRAMANA PHARMACEUTICALS INC. (CA) 2022-06-14 — — US disclosed
US-20210188825-A1 COMPOUNDS CONTAINING POLYSUBSTITUTED BENZO[D][1,3]OXATHIOLE, BENZO[D][1,3]OXATHIOLE 3-OXIDE OR BENZO[D][1,3]OXATHIOLE 3,3-DIOXIDE AND METHODS/USES THEREOF AS AGONISTS OF G PROTEIN-COUPLED RECEPTOR 119 PRAMANA PHARMACEUTICALS INC. (CA) 2021-06-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210188825-A1 COMPOUNDS CONTAINING POLYSUBSTITUTED BENZO[D][1,3]OXATHIOLE, BENZO[D][1,3]OXATHIOLE 3-OXIDE OR BENZO[D][1,3]OXATHIOLE 3,3-DIOXIDE AND METHODS/USES THEREOF AS AGONISTS OF G PROTEIN-COUPLED RECEPTOR 119 GPR119, GPR27, GCGR GPR119 1/4885KCNH2 941/4885HCRTR1 101/4885
US-11358956-B2 Compounds containing polysubstituted benzo[d][1,3]oxathiole, benzo[d][1,3]oxathiole 3-oxide or benzo[d][1,3]oxathiole 3,3-dioxide and methods/uses thereof as agonists of G protein-coupled receptor 119 GPR119, GPR27, GCGR GPR119 1/4885KCNH2 941/4885HCRTR1 101/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.