Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2410792 | 0.86 | ALDH1A1 (0.45) | MAPK1RPS6KB1AURKAAURKBMAPT | |
| SCHEMBL2416337 | 0.82 | MAPK1 (0.42) | MAPK1MAPT | |
| SCHEMBL2420091 | 0.81 | CDK2 (0.42) | MAPK1AURKBMAPK8LMNAKDR | |
| SCHEMBL2417717 | 0.81 | CDK2 (0.48) | MAPK1AURKAMAPTCSNK2A2KDR | |
| SCHEMBL2417161 | 0.78 | LCK (0.41) | MAPTMAPK8CSNK2A2KDRPLK1 | |
| SCHEMBL2414213 | 0.77 | CDK2 (0.41) | MAPTLMNA | |
| SCHEMBL2419147 | 0.77 | CDK2 (0.47) | MAPK1RPS6KB1AURKAAURKBMAOB | |
| SCHEMBL2419140 | 0.77 | CDK2 (0.42) | MAPK1RPS6KB1AURKAAURKBMAPT | |
| SCHEMBL2417864 | 0.77 | RAB9A (0.44) | MAPK1MAOBMAPTCSNK2A2KDR | |
| SCHEMBL2414984 | 0.76 | ALDH1A1 (0.45) | AURKAMAPTCDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1530573-B1 | CONDENSED HETEROCYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-03-19 | — | — | EP | claimed |