Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 6/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.32 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4709592 | 0.83 | HTR3A (0.32) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL608352 | 0.80 | GRK6 (0.35) | — | |
| SCHEMBL5241801 | 0.73 | MEN1 (0.38) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL6170514 | 0.69 | STAT3 (0.34) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL589273 | 0.69 | MEN1 (0.44) | — | |
| SCHEMBL606988 | 0.68 | ADRB2 (0.38) | — | |
| SCHEMBL537046 | 0.67 | GRK6 (0.37) | — | |
| SCHEMBL537062 | 0.66 | GRK6 (0.36) | — | |
| SCHEMBL140764 | 0.65 | KCNH2 (0.37) | — | |
| SCHEMBL2675015 | 0.65 | GRK6 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1913004-A1 | 8-METHOXY-9H-ISOTHIAZOLO[5,4-B]QUINOLINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | Achillion Pharmaceuticals, Inc. (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007014308-A1 | 8-METHOXY-9H-ISOTHIAZOLO[5,4-B]QUINOLINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | ACHILLION PHARMACEUTICALS, INC. (US) | 2007-02-01 | — | — | WO | disclosed |