Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 5/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.37 |
| ▸ | PIM1 | P11309 | 4/20 | 0.37 |
| ▸ | PRKACA | P17612 | 4/20 | 0.37 |
| ▸ | CDK2 | P24941 | 4/20 | 0.37 |
| ▸ | GSK3B | P49841 | 4/20 | 0.37 |
| ▸ | HIPK2 | Q9H2X6 | 4/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.37 |
| ▸ | TACR1 | P25103 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | CLK2 | P49760 | 2/20 | 0.35 |
| ▸ | PRKX | P51817 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4708192 | 0.89 | SMN1; SMN2 (0.40) | IDO1TDO2CDC7MAP4K4PIM1 | |
| SCHEMBL4707185 | 0.87 | CDC7 (0.37) | IDO1TDO2CDC7MAP4K4PIM1 | |
| SCHEMBL4707796 | 0.84 | CDC7 (0.39) | IDO1TDO2CDC7MAP4K4PIM1 | |
| SCHEMBL4707422 | 0.83 | SMN1; SMN2 (0.40) | IDO1CDC7MAP4K4PIM1PRKACA | |
| SCHEMBL4705897 | 0.81 | PTAFR (0.40) | IDO1CDC7MAP4K4PIM1PRKACA | |
| SCHEMBL4705520 | 0.81 | PTAFR (0.39) | IDO1TDO2CDC7MAP4K4PIM1 | |
| SCHEMBL4706961 | 0.80 | IDO1 (0.40) | IDO1TDO2CDC7MAP4K4PIM1 | |
| SCHEMBL4790291 | 0.80 | PTGER4 (0.40) | CDC7MAP4K4PIM1PRKACACDK2 | |
| SCHEMBL4705280 | 0.80 | PTGER4 (0.40) | CDC7MAP4K4PIM1PRKACACDK2 | |
| SCHEMBL4706420 | 0.76 | IDO1 (0.44) | IDO1TDO2CDC7MAP4K4PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501809-B1 | TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-01-16 | — | — | EP | disclosed |