Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 10/20 | 0.37 |
| ▸ | CDC7 | O00311 | 3/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | PRKACA | P17612 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705280 | 1.00 | PTGER4 (0.40) | PTGER4RECQLTACR1CDC7MAP4K4 | |
| SCHEMBL4705321 | 0.83 | TACR1 (0.35) | PTGER4TACR1CDC7MAP4K4PIM1 | |
| SCHEMBL4705897 | 0.82 | PTAFR (0.40) | PTGER4CDC7MAP4K4PIM1PRKACA | |
| SCHEMBL4705520 | 0.80 | PTAFR (0.39) | PTGER4TACR1CDC7MAP4K4PIM1 | |
| SCHEMBL4705551 | 0.80 | CDC7 (0.42) | PTGER4TACR1CDC7MAP4K4PIM1 | |
| SCHEMBL4707828 | 0.80 | CDC7 (0.42) | PTGER4TACR1CDC7MAP4K4PIM1 | |
| SCHEMBL4707135 | 0.80 | IDO1 (0.39) | PTGER4TACR1CDC7MAP4K4PIM1 | |
| SCHEMBL4708192 | 0.78 | SMN1; SMN2 (0.40) | TACR1CDC7MAP4K4PIM1PRKACA | |
| SCHEMBL4707185 | 0.76 | CDC7 (0.37) | PTGER4CDC7MAP4K4PIM1PRKACA | |
| SCHEMBL4708037 | 0.75 | NISCH (0.41) | TACR1CDC7MAP4K4PIM1PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501809-B1 | TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-01-16 | — | — | EP | disclosed |