Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 19/20 | 0.73 |
| ▸ | HSP90AA1 | P07900 | 18/20 | 0.73 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.57 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4706050 | 0.97 | HSP90AB1 (0.75) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL1220796 | 0.91 | HSP90AB1 (0.81) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL1220798 | 0.91 | HSP90AB1 (0.81) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL5148103 | 0.91 | HSP90AB1 (0.70) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL5148105 | 0.91 | HSP90AB1 (0.70) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL5148467 | 0.90 | HSP90AA1 (0.90) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL5148470 | 0.90 | HSP90AA1 (0.90) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL4653288 | 0.90 | HSP90AB1 (0.77) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL4706799 | 0.89 | HSP90AB1 (0.77) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL5148112 | 0.89 | HSP90AB1 (0.77) | HSP90AB1HSP90AA1HSP90B1TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991525-A1 | CYCLOHEXYLAMINO, BENZENE, PYRIDINE, AND PYRIDAZINE DERIVATIVES | Serenex, Inc. (US) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007101156-A1 | CYCLOHEXYLAMINO, BENZENE, PYRIDINE, AND PYRIDAZINE DERIVATIVES | SERENEX, INC. (US) | 2007-09-07 | — | — | WO | disclosed |
| US-20070207984-A1 | Cyclohexylamino Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2007-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070207984-A1 | Cyclohexylamino Benzene, Pyridine, and Pyridazine Derivatives | HRH4, P2RX4, CDK4 | HSP90AB1 2805/4885HSP90AA1 3248/4885HSP90B1 3218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.