Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.32 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5518587 | 0.96 | MAPT (0.38) | KDM4EMAPTALDH1A1DPP4LMNA | |
| SCHEMBL5512978 | 0.90 | KDM4E (0.34) | KDM4EMAPTALDH1A1DPP4LMNA | |
| SCHEMBL5517835 | 0.88 | MAPT (0.35) | KDM4EMAPTALDH1A1MAPK1KMT2A | |
| SCHEMBL6093093 | 0.86 | KDM4E (0.31) | KDM4EMAPT | |
| SCHEMBL5509238 | 0.85 | MAPT (0.41) | KDM4EMAPTALDH1A1LMNAKMT2A | |
| SCHEMBL6095019 | 0.85 | ALDH1A1 (0.33) | MAPTALDH1A1MAPK1 | |
| SCHEMBL5516128 | 0.85 | MAPT (0.43) | KDM4EMAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL5508711 | 0.85 | KDM4E (0.38) | KDM4EMAPTALDH1A1DPP4LMNA | |
| SCHEMBL5509867 | 0.83 | KDM4E (0.40) | KDM4EMAPTALDH1A1DPP4LMNA | |
| SCHEMBL5512817 | 0.83 | KDM4E (0.42) | KDM4EMAPTALDH1A1DPP4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1469000-B1 | NOVEL CRYSTALLINE TRICYCLIC TRIAZOLOBENZAZEPINE DERIVATIVE | MEIJI SEIKA KAISHA (JP) | 2008-10-08 | — | — | EP | disclosed |
| US-7238812-B2 | Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic agents | MEJI SEIKA KAISHA, LTD. (JP) | 2007-07-03 | — | — | US | disclosed |
| US-20060074074-A1 | Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic agents | MEIJI SEIKA PHARMA CO., LTD. (JP) | 2006-04-06 | — | — | US | disclosed |
| US-7022860-B2 | Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic agents | MEIJI SEIKA KAISHA, LTD. (JP) | 2006-04-04 | — | — | US | disclosed |
| US-7002009-B2 | Crystalline tricyclic triazolobenzazepine derivative | MEIJI SEIKA KAISHA, LTD. (JP) | 2006-02-21 | — | — | US | disclosed |
| US-20050020579-A1 | Novel crystalline tricyclic triazolobenzazepine derivative | MEIJI SEIKA PHARMA CO., LTD. (JP) | 2005-01-27 | — | — | US | disclosed |
| EP-1469000-A1 | NOVEL CRYSTALLINE TRICYCLIC TRIAZOLOBENZAZEPINE DERIVATIVE | MEIJI SEIKA KAISHA LTD. (JP) | 2004-10-20 | — | — | EP | disclosed |
| EP-1026167-B1 | TRICYCLIC TRIAZOLOBENZAZEPINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND ANTIALLERGIC AGENTS | MEIJI SEIKA KAISHA (JP) | 2003-03-05 | — | — | EP | disclosed |
| US-20020137739-A1 | Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic agents | MEIJI SEIKA PHARMA CO., LTD. (JP) | 2002-09-26 | — | — | US | disclosed |
| US-6372735-B1 | ANTIHISTAMINES | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-04-16 | — | — | US | disclosed |
| EP-1026167-A1 | TRICYCLIC TRIAZOLOBENZAZEPINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND ANTIALLERGIC | MEIJI SEIKA KAISHA LTD. (JP) | 2000-08-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020579-A1 | Novel crystalline tricyclic triazolobenzazepine derivative | GRIN2C, HTR2C, HTR2B | KDM4E 873/4885MAPT 354/4885ALDH1A1 1411/4885 |
| US-20060074074-A1 | Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic agents | HRH4, CYP2D6, CYP2B6 | KDM4E 752/4885MAPT 3031/4885ALDH1A1 959/4885 |
| US-20020137739-A1 | Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic agents | HRH4, CYP3A4, TPH1 | KDM4E 547/4885MAPT 3223/4885ALDH1A1 691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.