Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORB | Q92753 | 8/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tradipitant SCHEMBL2898629 | 0.95 | RORB (0.42) | RORBCDC7RORCMAPK1IDH1 | |
| Tradipitant SCHEMBL29810017 | 0.95 | RORB (0.42) | RORBCDC7RORCMAPK1IDH1 | |
| SCHEMBL4708122 | 0.92 | RORB (0.39) | RORBCDC7RORCIDH1GRM2 | |
| SCHEMBL4706981 | 0.92 | IDH1 (0.42) | RORBRORCIDH1 | |
| SCHEMBL25479760 | 0.91 | RORB (0.39) | RORBCDC7RORCMAPK1IDH1 | |
| SCHEMBL4707594 | 0.90 | RORB (0.43) | RORBRORCGRM2 | |
| SCHEMBL4707172 | 0.90 | RORB (0.46) | RORBRORCGRM2 | |
| SCHEMBL4705919 | 0.88 | KDR (0.37) | CDC7RORCGRM2KDR | |
| SCHEMBL4706229 | 0.87 | IDH1 (0.44) | RORBRORCIDH1GRM2KDR | |
| SCHEMBL4705482 | 0.87 | RORB (0.41) | RORBRORCIDH1GRM2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501809-B1 | TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-01-16 | — | — | EP | disclosed |
| CN-1312136-C | Triazole derivatives as tachykinin receptor antagonists | LILLY CO ELI (US) | 2007-04-25 | — | — | CN | disclosed |