Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | CDK4 | P11802 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 5/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | GLS | O94925 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2415752 | 0.86 | AURKA (0.51) | KITFLT3NPC1RAB9AKMT2A | |
| SCHEMBL2418708 | 0.82 | RAB9A (0.42) | CDK2CCNA2CCNA1NPC1RAB9A | |
| SCHEMBL2420091 | 0.81 | CDK2 (0.42) | CDK2CCNA2CCNA1FLT3NPC1 | |
| SCHEMBL2417074 | 0.79 | MAPT (0.46) | CDK2CCNA2CCNA1FLT3NPC1 | |
| SCHEMBL2416754 | 0.79 | SMN1; SMN2 (0.44) | CDK2CCNA2CCNA1KITNPC1 | |
| SCHEMBL2422194 | 0.79 | ALDH1A1 (0.40) | CDK2CCNA2CCNA1NPC1RAB9A | |
| SCHEMBL2415994 | 0.79 | KMT2A (0.42) | CDK2CCNA2CCNA1NPC1RAB9A | |
| SCHEMBL2416181 | 0.78 | MAPT (0.49) | NPC1RAB9AKMT2ALMNASMN1; SMN2 | |
| SCHEMBL2415989 | 0.78 | MAPT (0.46) | GAAKMT2ASMN1; SMN2GLSMAPT | |
| SCHEMBL2414063 | 0.78 | AURKA (0.60) | KITFLT3AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1530573-B1 | CONDENSED HETEROCYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-03-19 | — | — | EP | claimed |