Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4713075 | 0.91 | CA12 (0.54) | CA12CA1CA9CYP2D6KDM4E | |
| SCHEMBL4710499 | 0.87 | CA12 (0.55) | CA12CA1CA9CYP2D6KDM4E | |
| SCHEMBL4712795 | 0.78 | ALDH1A1 (0.64) | CA12CA1CA9KDM4EALDH1A1 | |
| SCHEMBL4711653 | 0.78 | CA12 (0.45) | CA12CA1CA9KDM4EALDH1A1 | |
| SCHEMBL30043665 | 0.75 | CA1 (0.61) | CA12CA1CA9KDM4EALDH1A1 | |
| SCHEMBL840971 | 0.75 | CA1 (0.61) | CA12CA1CA9KDM4EALDH1A1 | |
| SCHEMBL17923729 | 0.74 | PREP (0.41) | CA12CA1CA9CYP2D6 | |
| SCHEMBL24623215 | 0.73 | CYP2D6 (0.63) | CA12CA1CA9CYP2D6KDM4E | |
| SCHEMBL9797535 | 0.73 | CYP2D6 (0.68) | CA12CA1CA9CYP2D6KDM4E | |
| SCHEMBL29975674 | 0.73 | CYP2D6 (0.68) | CA12CA1CA9CYP2D6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812417-B1 | NOVEL 2H-CHROMENE DERIVATIVES AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-10-29 | — | — | EP | disclosed |
| EP-1812417-A1 | NOVEL 2H-CHROMENE DERIVATIVES AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-08-01 | — | — | EP | disclosed |
| US-20060166933-A1 | Novel 2H-chromene derivatives as selective estrogen receptor modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-27 | — | — | US | disclosed |
| WO-2006055694-A1 | NOVEL 2H-CHROMENE DERIVATIVES AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060166933-A1 | Novel 2H-chromene derivatives as selective estrogen receptor modulators | ESR2, ESR1, GPER1 | CA12 3325/4885CA1 4266/4885CA9 3943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.