SCHEMBL840971

SCHEMBL840971

CC(C)(C)[Si](C)(C)Oc1ccc2c(=O)c3ccc(O[Si](C)(C)C(C)(C)C)cc3oc2c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 5/20 0.61
CA12 O43570 4/20 0.61
CA9 Q16790 4/20 0.61
MAOA P21397 3/20 0.53
NPC1 O15118 3/20 0.53
RAB9A P51151 3/20 0.53
KDM4E B2RXH2 4/20 0.44
ALDH1A1 P00352 4/20 0.44
HPGD P15428 3/20 0.44
MAPT P10636 3/20 0.44
CASP3 P42574 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
SENP8 Q96LD8 1/20 0.44
SENP7 Q9BQF6 1/20 0.44
SENP6 Q9GZR1 1/20 0.44
MEN1 O00255 2/20 0.43
TP53 P04637 2/20 0.43
KMT2A Q03164 2/20 0.43
HSD17B10 Q99714 2/20 0.43
CYP2C9 P11712 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30043665 1.00 CA1 (0.61) CA1CA12CA9MAOANPC1
SCHEMBL8677800 0.93 MAOA (0.65) CA1CA12CA9MAOANPC1
SCHEMBL12909293 0.93 CA12 (0.55) CA1CA12CA9MAOANPC1
SCHEMBL1884168 0.83 CA12 (0.53) CA1CA12CA9MAOANPC1
SCHEMBL1885693 0.83 CA12 (0.53) CA1CA12CA9MAOANPC1
SCHEMBL29853363 0.83 MAPT (0.63) CA1CA12CA9NPC1RAB9A
SCHEMBL26781086 0.83 MAPT (0.63) CA1CA12CA9NPC1RAB9A
SCHEMBL4712795 0.82 ALDH1A1 (0.64) CA1CA12CA9MAOANPC1
SCHEMBL21113351 0.80 CA12 (0.43) CA1CA12CA9MAOANPC1
SCHEMBL30507514 0.80 CA12 (0.53) CA1CA12CA9MAOARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4328586-A1 FLUORESCENT STAINING METHOD OSAKA UNIVERSITY (JP) 2024-02-28 EP disclosed
WO-2023132337-A1 FLUORESCENT STAINING METHOD 国立大学法人大阪大学 2023-07-13 WO disclosed
US-20230152226-A1 OPTICAL SENSORS LUMIRADX UK LTD (GB) 2023-05-18 US disclosed
US-20230152226-A1 OPTICAL SENSORS LUMIRADX UK LTD (GB) 2023-05-18 US disclosed
EP-4121744-A1 OPTICAL SENSORS FOR DETECTING THE PRESENCE OR AMOUNT OF A TARGET PRESENT IN A SAMPLE LUMIRADX UK LTD (GB) 2023-01-25 EP disclosed
US-11519014-B2 Specific substrate of an ALDH isoenzyme ADVANCED BIODESIGN (FR) 2022-12-06 US disclosed
WO-2021189057-A1 OPTICAL SENSORS FOR DETECTING THE PRESENCE OR AMOUNT OF A TARGET PRESENT IN A SAMPLE LUMIRADX UK LTD. (GB) 2021-09-23 WO disclosed
US-20210072241-A1 FLUORESCENT PROBE FOR DETECTING CARBOXYPEPTIDASE ACTIVITY THE UNIVERSITY OF TOKYO (JP) 2021-03-11 US disclosed
US-20190233871-A1 SPECIFIC SUBSTRATE OF AN ALDH ISOENZYME ADVANCED BIODESIGN (FR) 2019-08-01 US disclosed
US-20180305329-A1 XANTHINE COMPOUND AND USE THEREOF GORYO CHEMICAL, INC. (JP) 2018-10-25 US disclosed
US-7868147-B2 substantially no fluorescent before the cleavage but highly fluorescent after the cleavage; traps a target substance such as an enzyme and emits fluorescence Nagano, Tetsuo (JP) 2011-01-11 US disclosed
US-20090317914-A1 FLUORESCENT PROBE THE UNIVERSITY OF TOKYO (JP) 2009-12-24 US disclosed
US-7524974-B2 Fluorescent probe Nagano, Tetsuo (JP) 2009-04-28 US disclosed
WO-2008075955-A2 PROCESS FOR THE PREPARATION OF 1,4,5-TRISUBSTITUTED TRIAZOLES AND 3,4,5-TRISUBSTITUTED TRIAZOLES STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) 2008-06-26 WO disclosed
US-20080014602-A1 Fluorescent Probe SEKISUI MEDICAL CO., LTD. (JP) 2008-01-17 US disclosed
US-20080014602-A1 Fluorescent Probe SEKISUI MEDICAL CO., LTD. (JP) 2008-01-17 US disclosed
EP-1674579-A1 FLUORESCENT PROBE DAIICHI PURE CHEMICALS CO., LTD. (JP) 2006-06-28 EP disclosed
EP-0314480-B1 Fluorescent indicator dyes for calcium working at long wavelengths UNIV CALIFORNIA (US) 1994-09-14 EP disclosed
US-5049673-A Fluorescent indicator dyes for calcium working at long wavelengths THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1991-09-17 US disclosed
EP-0314480-A2 Fluorescent indicator dyes for calcium working at long wavelengths THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1989-05-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090317914-A1 FLUORESCENT PROBE H1-10, H1-0, NHERF1 CA1 799/4885CA12 2001/4885CA9 679/4885
US-20210072241-A1 FLUORESCENT PROBE FOR DETECTING CARBOXYPEPTIDASE ACTIVITY CPN1, DNPEP, ANPEP CA1 160/4885CA12 72/4885CA9 111/4885
US-20180305329-A1 XANTHINE COMPOUND AND USE THEREOF CYP3A43, CYP3A4, CYP1A1 CA1 821/4885CA12 1985/4885CA9 1797/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.