Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | ALDH1A2 | O94788 | 2/20 | 0.47 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.47 |
| ▸ | ALDH1B1 | P30837 | 2/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 2/20 | 0.46 |
| ▸ | CASP7 | P55210 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4712015 | 0.89 | ALDH1A1 (0.46) | ALDH1A1ALDH1A2ALDH2ALDH1B1HPGD | |
| SCHEMBL4708821 | 0.88 | ALDH1A1 (0.47) | ALDH1A1ALDH1A2ALDH2ALDH1B1HPGD | |
| SCHEMBL4856691 | 0.87 | TSHR (0.51) | ALDH1A1ALDH1A2ALDH2ALDH1B1ELANE | |
| SCHEMBL8238038 | 0.85 | ALDH1A1 (0.47) | ALDH1A1ALDH1A2ALDH2ALDH1B1HPGD | |
| SCHEMBL4713288 | 0.83 | HSD17B10 (0.50) | ALDH1A1ALDH1A2ALDH2ALDH1B1HPGD | |
| SCHEMBL4709238 | 0.82 | ALDH1A1 (0.46) | ALDH1A1ALDH1A2ALDH2ALDH1B1HPGD | |
| SCHEMBL4709144 | 0.80 | ELANE (0.50) | ALDH1A1ALDH1A2ALDH2ALDH1B1ELANE | |
| SCHEMBL4711081 | 0.79 | ALDH1A1 (0.48) | ALDH1A1ALDH1A2ALDH2ALDH1B1HPGD | |
| SCHEMBL4710884 | 0.78 | ALDH1A1 (0.59) | ALDH1A1ALDH1A2ALDH2ALDH1B1HPGD | |
| SCHEMBL4713181 | 0.77 | ELANE (0.53) | ALDH1A1ALDH1A2ALDH2ALDH1B1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957475-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007045876-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-04-26 | — | — | WO | disclosed |
| WO-2007045876-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-04-26 | — | — | WO | disclosed |