Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 5/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | CASP7 | P55210 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4709482 | 0.79 | ALDH1A1 (0.52) | ELANEHPGDCYP1A2ALDH1A1TSHR | |
| SCHEMBL4708821 | 0.77 | ALDH1A1 (0.47) | MAOBTDP1HPGDCYP1A2ALDH1A1 | |
| SCHEMBL4709072 | 0.77 | ALDH1A1 (0.47) | ELANEMAOBTDP1HPGDCYP1A2 | |
| SCHEMBL4708997 | 0.76 | ALDH1A1 (0.49) | ELANEHPGDCYP1A2ALDH1A1TSHR | |
| SCHEMBL8238038 | 0.75 | ALDH1A1 (0.47) | MAOBTDP1HPGDCYP1A2ALDH1A1 | |
| SCHEMBL4709144 | 0.74 | ELANE (0.50) | ELANEMAOBTDP1HPGDCYP1A2 | |
| SCHEMBL4711081 | 0.73 | ALDH1A1 (0.48) | MAOBTDP1HPGDCYP1A2ALDH1A1 | |
| SCHEMBL4710884 | 0.72 | ALDH1A1 (0.59) | HPGDCYP1A2ALDH1A1TSHRKDM4E | |
| SCHEMBL8243431 | 0.72 | ALDH1A1 (0.56) | HPGDCYP1A2ALDH1A1TSHRKDM4E | |
| SCHEMBL4713288 | 0.71 | HSD17B10 (0.50) | MAOBTDP1HPGDCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957475-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007045876-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-04-26 | — | — | WO | disclosed |
| WO-2007045876-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-04-26 | — | — | WO | disclosed |