Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.46 |
| ▸ | AXL | P30530 | 5/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 9/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 4/20 | 0.43 |
| ▸ | MERTK | Q12866 | 2/20 | 0.42 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5009415 | 0.89 | AXL (0.45) | KDRAXLPDGFRBCSF1RPDGFRA | |
| SCHEMBL4708410 | 0.87 | KDR (0.51) | KDRPDGFRBCSF1RPDGFRAMET | |
| SCHEMBL2175230 | 0.78 | KDR (0.53) | KDRAXLPDGFRBCSF1RPDGFRA | |
| SCHEMBL2175628 | 0.74 | MET (0.50) | KDRAXLPDGFRBCSF1RPDGFRA | |
| SCHEMBL4710076 | 0.73 | PDGFRB (0.72) | KDRPDGFRBCSF1RPDGFRAFLT3 | |
| SCHEMBL2176270 | 0.71 | PDGFRB (0.66) | KDRAXLPDGFRBCSF1RPDGFRA | |
| SCHEMBL5009418 | 0.70 | KDR (0.56) | KDRAXLPDGFRBCSF1RPDGFRA | |
| SCHEMBL2173726 | 0.68 | KDR (0.73) | KDRAXLPDGFRBCSF1RPDGFRA | |
| SCHEMBL2172121 | 0.68 | PDGFRB (0.71) | KDRAXLPDGFRBCSF1RPDGFRA | |
| SCHEMBL4514154 | 0.68 | KDR (0.52) | KDRAXLPDGFRBCSF1RPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994025-A1 | QUINOLINE DERIVATIVES | AstraZeneca AB (SE) | 2008-11-26 | — | — | EP | claimed |
| WO-2007099326-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-07 | — | — | WO | claimed |
| EP-1994025-A1 | QUINOLINE DERIVATIVES | AstraZeneca AB (SE) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007099326-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-07 | — | — | WO | disclosed |