Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FHIT | P49789 | 2/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | GLA | P06280 | 3/20 | 0.63 |
| ▸ | GAA | P10253 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | CASP1 | P29466 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | CASP7 | P55210 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 8/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4710609 | 0.85 | FHIT (0.71) | FHITALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL4710927 | 0.84 | FHIT (0.70) | FHITALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL4708929 | 0.83 | FHIT (0.69) | FHITALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL4708976 | 0.83 | KDM4E (0.70) | FHITALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL4711017 | 0.83 | KDM4E (0.95) | FHITALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL20246700 | 0.82 | FHIT (0.70) | FHITALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL4709622 | 0.81 | KDM4E (0.67) | FHITALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL4712030 | 0.81 | KDM4E (0.77) | FHITALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL4711880 | 0.80 | KDM4E (0.95) | FHITALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL4709413 | 0.80 | KDM4E (0.68) | FHITALDH1A1KDM4EHSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957475-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007045876-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-04-26 | — | — | WO | disclosed |
| WO-2007045876-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-04-26 | — | — | WO | disclosed |