Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | P2RY6 | Q15077 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | SRC | P12931 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4716032 | 0.81 | KDM4E (0.42) | KMT2ANPC1RAB9AP2RY6KDM4E | |
| SCHEMBL4711002 | 0.74 | MEN1 (0.36) | MEN1KMT2ANPC1RAB9AATM | |
| SCHEMBL4713994 | 0.69 | KDM4E (0.53) | NPC1RAB9AP2RY6KDM4EHTT | |
| SCHEMBL4716805 | 0.66 | KDM4E (0.43) | KDM4EALDH1A1LMNAHTTPARP1 | |
| Hydrochloric Acid SCHEMBL4715473 | 0.65 | JAK2 (0.39) | MEN1KMT2ANPC1RAB9AATM | |
| SCHEMBL239224 | 0.65 | NPC1 (0.43) | NPC1RAB9AKDM4EALDH1A1HTT | |
| SCHEMBL2755157 | 0.62 | RAB9A (0.46) | MEN1KMT2ANPC1RAB9AATM | |
| SCHEMBL236540 | 0.59 | AURKA (0.38) | NPC1RAB9AATMTRPV1KDM4E | |
| SCHEMBL238557 | 0.59 | RAB9A (0.39) | MEN1KMT2ANPC1RAB9AATM | |
| SCHEMBL4716030 | 0.59 | PLAT (0.41) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641454-B1 | PYRAZOLO[3,4-B]PYRIDIN-6-ONES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2008-10-01 | — | — | EP | disclosed |
| US-7300943-B2 | GSK-3 inhibitors | PFIZER INC. (US) | 2007-11-27 | — | — | US | disclosed |
| US-20050026946-A1 | GSK-3 inhibitors | PFIZER INC | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026946-A1 | GSK-3 inhibitors | GSK3B, GSK3A, GSKIP | MEN1 836/4885KMT2A 1729/4885NPC1 1306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.