Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | LTK | P29376 | 1/20 | 0.32 |
| ▸ | GRK5 | P34947 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | PRKX | P51817 | 1/20 | 0.32 |
| ▸ | NEK2 | P51955 | 1/20 | 0.32 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4711494 | 0.84 | ALDH1A1 (0.43) | KDM4EHSD17B10ALDH1A1PARP1HPGD | |
| SCHEMBL4713927 | 0.76 | HCAR1 (0.31) | — | |
| SCHEMBL4716803 | 0.70 | PARP1 (0.43) | KDM4EHSD17B10ALDH1A1PARP1HPGD | |
| SCHEMBL4714881 | 0.70 | PARP1 (0.33) | PARP1 | |
| SCHEMBL4713994 | 0.67 | KDM4E (0.53) | KDM4EHSD17B10PARP1HPGDJAK1 | |
| SCHEMBL4711005 | 0.66 | MEN1 (0.37) | KDM4EHSD17B10ALDH1A1PARP1HPGD | |
| SCHEMBL1694536 | 0.65 | PARP1 (0.46) | KDM4EHSD17B10ALDH1A1PARP1HPGD | |
| Hydrochloric Acid SCHEMBL4715433 | 0.61 | KDM4E (0.59) | KDM4EHSD17B10ALDH1A1HPGDJAK1 | |
| SCHEMBL6845090 | 0.59 | KDM4E (0.58) | KDM4EHSD17B10ALDH1A1PARP1HPGD | |
| SCHEMBL12322233 | 0.55 | PARP1 (0.50) | PARP1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641454-B1 | PYRAZOLO[3,4-B]PYRIDIN-6-ONES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2008-10-01 | — | — | EP | disclosed |
| EP-1641455-B1 | PYRAZOLO[3,4-B]PYRIDIN-6-ONES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2008-08-06 | — | — | EP | disclosed |
| US-7300943-B2 | GSK-3 inhibitors | PFIZER INC. (US) | 2007-11-27 | — | — | US | disclosed |
| US-7300944-B2 | Pyrazolo[3,4-b]pyridin-6-ones as GSK-3 inhibitors | PFIZER INC. (US) | 2007-11-27 | — | — | US | disclosed |
| EP-1641454-A1 | PYRAZOLO[3,4-B]PYRIDIN-6-ONES AS GSK-3 INHIBITORS | Pfizer Products Inc. (US) | 2006-04-05 | — | — | EP | disclosed |
| US-20050026946-A1 | GSK-3 inhibitors | PFIZER INC | 2005-02-03 | — | — | US | disclosed |
| WO-2005000303-A1 | PYRAZOLO`3,4-B!PYRIDIN-6-ONES AS GSK-3 INHIBITORS | PFIZER PRODUCTS INC. (US) | 2005-01-06 | — | — | WO | disclosed |
| US-20040266815-A1 | Pyrazolo[3,4-b]pyridin-6-ones as GSK-3 inhibitors | PFIZER INC | 2004-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026946-A1 | GSK-3 inhibitors | GSK3B, GSK3A, GSKIP | KDM4E 2004/4885HSD17B10 387/4885ALDH1A1 1553/4885 |
| US-20040266815-A1 | Pyrazolo[3,4-b]pyridin-6-ones as GSK-3 inhibitors | GSK3B, GSK3A, GSKIP | KDM4E 2008/4885HSD17B10 1084/4885ALDH1A1 1349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.