Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 13/20 | 0.44 |
| ▸ | NSD3 | Q9BZ95 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | TTK | P33981 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10842926 | 0.83 | ALDH1A1 (0.46) | KDM5BGSK3BCDC7ROCK2MAP4K4 | |
| SCHEMBL4759558 | 0.79 | GSK3B (0.55) | GSK3B | |
| SCHEMBL31070715 | 0.76 | EP300 (0.48) | — | |
| SCHEMBL20415037 | 0.76 | LMNA (0.38) | — | |
| SCHEMBL18471238 | 0.74 | FFAR1 (0.37) | — | |
| SCHEMBL83040 | 0.74 | GSK3B (0.43) | GSK3BCDC7ROCK2MAP4K4PRKACA | |
| SCHEMBL32667263 | 0.74 | MAP4K1 (0.39) | AURKATTKAURKBINCENP | |
| SCHEMBL15261616 | 0.73 | FFAR1 (0.35) | — | |
| SCHEMBL15262765 | 0.71 | ALDH1A1 (0.43) | NSD3 | |
| SCHEMBL22341550 | 0.71 | CHEK1 (0.41) | KDM5BPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001863-A1 | 2-(CYCLIC AMINO)-PYRIMIDONE DERIVATIVES AS TPK1 INHIBITORS | Mitsubishi Tanabe Pharma Corporation (JP) | 2008-12-17 | — | — | EP | claimed |
| WO-2007119463-A1 | 2-(CYCLIC AMINO)-PYRIMIDONE DERIVATIVES AS TPK1 INHIBITORS | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2007-10-25 | — | — | WO | claimed |
| EP-2057141-B1 | PYRIMIDONE COMPOUNDS AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2011-10-26 | — | — | EP | disclosed |
| CN-1764650-B | 2, 3, 6-trisubstituted-4-pyrimidone derivatives | MITSUBISHI PHARMA CORP | 2010-06-16 | — | — | CN | disclosed |
| EP-2001863-A1 | 2-(CYCLIC AMINO)-PYRIMIDONE DERIVATIVES AS TPK1 INHIBITORS | Mitsubishi Tanabe Pharma Corporation (JP) | 2008-12-17 | — | — | EP | disclosed |
| CN-100376576-C | Substituted 2- (diaza-bicyclo-alkyl) -pyrimidone derivatives | SANOFI SYNTHELABO (FR) | 2008-03-26 | — | — | CN | disclosed |
| WO-2007119463-A1 | 2-(CYCLIC AMINO)-PYRIMIDONE DERIVATIVES AS TPK1 INHIBITORS | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2007-10-25 | — | — | WO | disclosed |
| CN-1777603-A | Substituted 2- (diaza-bicyclo-alkyl) -pyrimidone derivatives | SANOFI SYNTHELABO (FR) | 2006-05-24 | — | — | CN | disclosed |
| CN-1764650-A | 2, 3, 6-trisubstituted-4-pyrimidone derivatives | MITSUBISHI PHARMA CORP (JP) | 2006-04-26 | — | — | CN | disclosed |