Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2088816 | 0.89 | SYK (0.68) | SYKALDH1A1KDM4ESMN1; SMN2TSHR | |
| SCHEMBL4472638 | 0.84 | MEN1 (0.64) | SYKALDH1A1KDM4ESMN1; SMN2MEN1 | |
| Morclofone SCHEMBL554800 | 0.83 | SYK (0.60) | SYKALDH1A1KDM4ESMN1; SMN2TSHR | |
| SCHEMBL10196165 | 0.82 | SYK (1.00) | SYKALDH1A1TSHRCYP2D6MEN1 | |
| SCHEMBL4714483 | 0.82 | SYK (0.59) | SYKALDH1A1KDM4ESMN1; SMN2TSHR | |
| SCHEMBL12435658 | 0.81 | SYK (0.77) | SYKSMN1; SMN2TSHRCYP2D6MEN1 | |
| SCHEMBL13380211 | 0.79 | CYP2D6 (0.64) | ALDH1A1KDM4ESMN1; SMN2TSHRCYP2D6 | |
| SCHEMBL523271 | 0.78 | SYK (0.71) | SYKALDH1A1SMN1; SMN2TSHRCYP2D6 | |
| SCHEMBL23195558 | 0.78 | KDM4E (0.61) | SYKALDH1A1KDM4ESMN1; SMN2TSHR | |
| SCHEMBL3930808 | 0.78 | KDM4E (0.61) | SYKALDH1A1KDM4ESMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373257-B9 | INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES | VERTEX PHARMA (US) | 2008-10-15 | — | — | EP | disclosed |
| EP-1373257-B1 | INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES | VERTEX PHARMA (US) | 2007-11-28 | — | — | EP | disclosed |