Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4713536 | 0.89 | MAPK1 (0.44) | SMN1; SMN2MAPK1S1PR4S1PR5FFAR4 | |
| SCHEMBL4019783 | 0.78 | MAPK1 (0.41) | SMN1; SMN2MAPK1S1PR4S1PR5FFAR4 | |
| SCHEMBL6719215 | 0.71 | TSHR (0.41) | SMN1; SMN2MAPK1TSHRLMNA | |
| SCHEMBL4024326 | 0.69 | MAPK1 (0.46) | SMN1; SMN2MAPK1S1PR4S1PR5FFAR4 | |
| SCHEMBL4714650 | 0.67 | MEN1 (0.47) | SMN1; SMN2TSHRLMNAMAPT | |
| SCHEMBL4717989 | 0.67 | MEN1 (0.47) | SMN1; SMN2TSHRLMNAMAPT | |
| SCHEMBL5047436 | 0.67 | MAPT (0.36) | SMN1; SMN2MAPK1TSHRELANELMNA | |
| SCHEMBL5039556 | 0.66 | CAPN1 (0.38) | SMN1; SMN2ELANELMNAGAA | |
| SCHEMBL5047441 | 0.66 | BCHE (0.44) | ELANELMNAMAPT | |
| SCHEMBL4717987 | 0.65 | TSHR (0.47) | SMN1; SMN2TSHRLMNATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1986637-A1 | SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF BACTERIAL INFECTIONS | Laboratoires Serono SA (CH) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007093557-A1 | SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF BACTERIAL INFECTIONS | LABORATOIRES SERONO S.A. (CH) | 2007-08-23 | — | — | WO | disclosed |