Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.48 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.48 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4711585 | 1.00 | USP2 (0.49) | USP2MAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL4713003 | 0.88 | PTGDR2 (0.45) | MAPTRAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL4710664 | 0.88 | PTGDR2 (0.45) | MAPTRAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL4710531 | 0.80 | TSHR (0.44) | MAPTALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL4710729 | 0.80 | TSHR (0.44) | MAPTALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL4710055 | 0.80 | KMT2A (0.44) | USP2MAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL4710053 | 0.80 | KMT2A (0.44) | USP2MAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL2011265 | 0.74 | USP2 (0.58) | USP2MAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL4713064 | 0.73 | RAB9A (0.46) | USP2MAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL4713060 | 0.73 | RAB9A (0.46) | USP2MAPTALDH1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | claimed |
| EP-0998459-A2 | PYRIDINE DERIVATIVES | Novartis AG (CH) | 2000-05-10 | — | — | EP | claimed |
| WO-1999002497-A2 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 1999-01-21 | — | — | WO | claimed |
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | disclosed |