Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4710664 | 1.00 | PTGDR2 (0.45) | PTGDR2KMT2AMEN1GAAKDM4E | |
| SCHEMBL4711585 | 0.88 | USP2 (0.49) | KMT2AMEN1KDM4EPKMRAB9A | |
| SCHEMBL4711587 | 0.88 | USP2 (0.49) | KMT2AMEN1KDM4EPKMRAB9A | |
| SCHEMBL4710055 | 0.81 | KMT2A (0.44) | KMT2AMEN1GAAKDM4EHTT | |
| SCHEMBL4710053 | 0.81 | KMT2A (0.44) | KMT2AMEN1GAAKDM4EHTT | |
| SCHEMBL7267902 | 0.79 | FGFR1 (0.44) | KMT2AMEN1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL4713060 | 0.77 | RAB9A (0.46) | KMT2AMEN1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL4713064 | 0.77 | RAB9A (0.46) | KMT2AMEN1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL4713933 | 0.76 | ENPP2 (0.39) | KMT2AMEN1GAAKDM4EMAPT | |
| SCHEMBL4713931 | 0.76 | ENPP2 (0.39) | KMT2AMEN1GAAKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | claimed |
| EP-0998459-A2 | PYRIDINE DERIVATIVES | Novartis AG (CH) | 2000-05-10 | — | — | EP | claimed |
| WO-1999002497-A2 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 1999-01-21 | — | — | WO | claimed |
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | disclosed |