Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TAS1R3 | Q7RTX0 | 5/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 5/20 | 0.47 |
| ▸ | TAS1R2 | Q8TE23 | 5/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16709695 | 0.86 | TRPV1 (0.52) | TRPV1LMNATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL22623413 | 0.86 | KDM4E (0.48) | TRPV1LMNAKDM4EPOLBMAPT | |
| SCHEMBL28748640 | 0.81 | S1PR1 (0.48) | TRPV1LMNAKDM4EPOLBMAPT | |
| SCHEMBL22813952 | 0.80 | TRPV1 (0.47) | TRPV1LMNATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL12669383 | 0.80 | TRPV1 (0.47) | TRPV1LMNATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL10462960 | 0.79 | TAS1R3 (0.62) | TAS1R3TAS1R1TAS1R2CA12CA1 | |
| SCHEMBL4016100 | 0.78 | TRPV1 (0.51) | TRPV1LMNATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL14304242 | 0.78 | PDPK1 (0.55) | TRPV1PDE10AADRA2AADRA2BADRA2C | |
| SCHEMBL11775638 | 0.78 | TAS1R3 (0.57) | POLBTAS1R3TAS1R1TAS1R2CYP11B1 | |
| SCHEMBL19446554 | 0.77 | TRPV1 (0.44) | TRPV1LMNATAS1R3TAS1R1TAS1R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1998774-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES TO ENHANCE MEMORY FUNCTION | Actelion Pharmaceuticals Ltd. (CH) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007105177-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES TO ENHANCE MEMORY FUNCTION | ACTELION PHARMACEUTICALS LTD (CH) | 2007-09-20 | — | — | WO | disclosed |