Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 5/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 5/20 | 0.43 |
| ▸ | TAS1R2 | Q8TE23 | 4/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 5/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 3/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4711698 | 0.77 | TRPV1 (0.53) | TRPV1TAS1R3TAS1R1TAS1R2PDE10A | |
| SCHEMBL20662806 | 0.76 | TAS1R3 (0.48) | TAS1R3TAS1R1TAS1R2LMNAMEN1 | |
| SCHEMBL16709695 | 0.75 | TRPV1 (0.52) | TRPV1TAS1R3TAS1R1TAS1R2PDE10A | |
| SCHEMBL14040509 | 0.75 | PDE10A (0.46) | TRPV1TAS1R3TAS1R1TAS1R2PDE10A | |
| SCHEMBL14304242 | 0.74 | PDPK1 (0.55) | TRPV1PDE10AOPRL1KCNH2ADRA2A | |
| SCHEMBL22813952 | 0.70 | TRPV1 (0.47) | TRPV1TAS1R3TAS1R1TAS1R2PDE10A | |
| SCHEMBL12669383 | 0.70 | TRPV1 (0.47) | TRPV1TAS1R3TAS1R1TAS1R2PDE10A | |
| SCHEMBL31231476 | 0.70 | SLC6A2 (0.44) | TRPV1PDE10AOPRL1KCNH2MAOB | |
| SCHEMBL1999695 | 0.69 | KMT2A (0.46) | TRPV1TAS1R3TAS1R1TAS1R2PDE10A | |
| SCHEMBL22032577 | 0.69 | CCR2 (0.40) | TRPV1TAS1R3TAS1R1TAS1R2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2995611-B1 | ALPHA-SUBSTITUTED GLYCINEAMIDE DERIVATIVE | KISSEI PHARMACEUTICAL (JP) | 2017-10-11 | — | — | EP | disclosed |