Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 9/20 | 0.50 |
| ▸ | NTRK2 | Q16620 | 5/20 | 0.50 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1924558 | 0.86 | NTRK1 (0.61) | NTRK1NTRK2NTRK3ACVRL1HTT | |
| SCHEMBL4708490 | 0.83 | NTRK1 (0.52) | NTRK1NTRK2NTRK3ACVRL1AURKA | |
| SCHEMBL12537484 | 0.79 | NTRK1 (0.48) | NTRK1NTRK2NTRK3 | |
| SCHEMBL1924225 | 0.77 | NTRK1 (0.67) | NTRK1NTRK2NTRK3ACVRL1 | |
| SCHEMBL3980576 | 0.76 | NTRK1 (0.69) | NTRK1NTRK2AURKAAURKB | |
| SCHEMBL12537616 | 0.76 | NTRK1 (0.68) | NTRK1NTRK2NTRK3POLBMAPT | |
| SCHEMBL12537492 | 0.75 | NTRK2 (0.51) | NTRK1NTRK2POLBMAPTRAB9A | |
| SCHEMBL1924406 | 0.75 | NTRK1 (0.78) | NTRK1NTRK2NTRK3HTTRAB9A | |
| SCHEMBL4078145 | 0.75 | NTRK1 (0.58) | NTRK1NTRK2NTRK3 | |
| SCHEMBL4081608 | 0.73 | NTRK1 (0.73) | NTRK1NTRK2NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948664-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | Brystol-Myers Squibb Company (US) | 2008-07-30 | — | — | EP | claimed |
| WO-2007061882-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-31 | — | — | WO | claimed |