Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 15/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 6/20 | 0.45 |
| ▸ | AXL | P30530 | 2/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14537222 | 0.84 | NTRK1 (0.67) | NTRK1NTRK2KCNH2NTRK3 | |
| SCHEMBL4708490 | 0.81 | NTRK1 (0.52) | NTRK1NTRK2AXLMERTKKCNH2 | |
| SCHEMBL4711702 | 0.79 | NTRK1 (0.50) | NTRK1NTRK2NTRK3 | |
| SCHEMBL12537616 | 0.76 | NTRK1 (0.68) | NTRK1NTRK2KCNH2NTRK3 | |
| SCHEMBL12537492 | 0.76 | NTRK2 (0.51) | NTRK1NTRK2 | |
| SCHEMBL1924948 | 0.74 | NTRK1 (0.69) | NTRK1NTRK2KCNH2NTRK3 | |
| SCHEMBL1925611 | 0.74 | NTRK1 (0.71) | NTRK1NTRK2 | |
| SCHEMBL3980576 | 0.74 | NTRK1 (0.69) | NTRK1NTRK2AXLMERTK | |
| SCHEMBL13869078 | 0.74 | NTRK1 (0.51) | NTRK1NTRK2AXLMERTKCSNK2A2 | |
| SCHEMBL1925304 | 0.73 | NTRK2 (0.79) | NTRK1NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948664-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-06-08 | — | — | EP | disclosed |