Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 12/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 8/20 | 0.52 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 3/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 2/20 | 0.35 |
| ▸ | FYN | P06241 | 2/20 | 0.35 |
| ▸ | LYN | P07948 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | MARK3 | P27448 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.35 |
| ▸ | GSK3A | P49840 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | BLK | P51451 | 2/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1924266 | 0.85 | NTRK1 (0.67) | NTRK1NTRK2AURKAAURKBKCNH2 | |
| SCHEMBL4711702 | 0.83 | NTRK1 (0.50) | NTRK1NTRK2ACVRL1AURKAAURKB | |
| SCHEMBL12537484 | 0.81 | NTRK1 (0.48) | NTRK1NTRK2KCNH2NTRK3AXL | |
| SCHEMBL12537616 | 0.76 | NTRK1 (0.68) | NTRK1NTRK2KCNH2NTRK3ERBB4 | |
| SCHEMBL12537492 | 0.76 | NTRK2 (0.51) | NTRK1NTRK2AURKACSF1RLCK | |
| SCHEMBL1924948 | 0.75 | NTRK1 (0.69) | NTRK1NTRK2KCNH2NTRK3KDR | |
| SCHEMBL3980576 | 0.75 | NTRK1 (0.69) | NTRK1NTRK2AURKAAURKBLCK | |
| SCHEMBL1924636 | 0.74 | NTRK1 (0.85) | NTRK1NTRK2AURKAAURKBCSF1R | |
| SCHEMBL1925029 | 0.73 | NTRK1 (0.66) | NTRK1NTRK2KCNH2 | |
| SCHEMBL14537222 | 0.72 | NTRK1 (0.67) | NTRK1NTRK2ACVRL1KCNH2NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948664-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | Brystol-Myers Squibb Company (US) | 2008-07-30 | — | — | EP | claimed |
| WO-2007061882-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-31 | — | — | WO | claimed |