Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAPDH | P04406 | 2/20 | 0.42 |
| ▸ | HSPA1A | P0DMV8 | 2/20 | 0.42 |
| ▸ | HSPA8 | P11142 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MASP2 | O00187 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | JUND | P17535 | 1/20 | 0.38 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.38 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | FOSB | P53539 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | UBE2N | P61088 | 1/20 | 0.38 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4713073 | 0.88 | GAPDH (0.47) | GAPDHHSPA1AHSPA8POLBPTPN7 | |
| SCHEMBL4711434 | 0.87 | GAPDH (0.43) | GAPDHHSPA1AHSPA8CYP3A4CYP2D6 | |
| SCHEMBL4712017 | 0.87 | GAPDH (0.44) | GAPDHHSPA1AHSPA8POLBPTPN7 | |
| SCHEMBL4712093 | 0.87 | GAPDH (0.44) | GAPDHHSPA1AHSPA8POLBPTPN7 | |
| SCHEMBL4712066 | 0.86 | CYP3A4 (0.35) | GAPDHHSPA1AHSPA8KDM4EMASP2 | |
| SCHEMBL4713160 | 0.85 | GAPDH (0.44) | GAPDHHSPA1AHSPA8PTPN7CYP3A4 | |
| SCHEMBL4715026 | 0.85 | GAPDH (0.44) | GAPDHHSPA1AHSPA8POLBPTPN7 | |
| SCHEMBL4712217 | 0.85 | GAPDH (0.44) | GAPDHHSPA1AHSPA8POLBPTPN7 | |
| SCHEMBL14143750 | 0.83 | KDM4E (0.39) | GAPDHHSPA1AHSPA8KDM4EMASP2 | |
| SCHEMBL6822472 | 0.81 | GAPDH (0.43) | GAPDHHSPA1AHSPA8CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412361-B1 | SUBSTITUTED 5,6,6A,11B-TETRAHYDRO-7-OXA-5-AZA-BENZO[C]FLUORENE-6-CARBOXYLIC ACID DERIVATIVES SERVING AS NMDA ANTAGONISTS | GRUENENTHAL GMBH (DE) | 2008-07-23 | — | — | EP | disclosed |
| US-7199130-B2 | Substituted 5,6,6a, 11b-tetrahydro-7-oxa-5-aza-benzo[c]fluorene-6-carboxylic acid compounds as NMDA-antagonists | GRUENENTHAL GMBH (DE) | 2007-04-03 | — | — | US | disclosed |
| US-7199130-B2 | Substituted 5,6,6a, 11b-tetrahydro-7-oxa-5-aza-benzo[c]fluorene-6-carboxylic acid compounds as NMDA-antagonists | GRUENENTHAL GMBH (DE) | 2007-04-03 | — | — | US | disclosed |