Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | HSPA1A | P0DMV8 | 4/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GAPDH | P04406 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | HSPA8 | P11142 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MASP2 | O00187 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | JUND | P17535 | 1/20 | 0.39 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14143776 | 0.84 | HSPA1A (0.35) | KDM4EHSPA1APTPN7MAPTGAPDH | |
| SCHEMBL4712064 | 0.83 | GAPDH (0.42) | KDM4EHSPA1APTPN7ALDH1A1MAPT | |
| SCHEMBL14143589 | 0.72 | GAPDH (0.32) | HSPA1APTPN7GAPDH | |
| SCHEMBL4713073 | 0.70 | GAPDH (0.47) | HSPA1APTPN7GAPDHPOLBHSPA8 | |
| SCHEMBL4711434 | 0.69 | GAPDH (0.43) | HSPA1AGAPDHHSPA8MEN1KMT2A | |
| SCHEMBL4712066 | 0.69 | CYP3A4 (0.35) | KDM4EHSPA1APTPN7ALDH1A1MAPT | |
| SCHEMBL4712093 | 0.69 | GAPDH (0.44) | HSPA1APTPN7GAPDHPOLBHSPA8 | |
| SCHEMBL4712017 | 0.69 | GAPDH (0.44) | HSPA1APTPN7GAPDHPOLBHSPA8 | |
| SCHEMBL4712217 | 0.67 | GAPDH (0.44) | HSPA1APTPN7GAPDHPOLBHSPA8 | |
| SCHEMBL4715026 | 0.67 | GAPDH (0.44) | HSPA1APTPN7GAPDHPOLBHSPA8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412361-B1 | SUBSTITUTED 5,6,6A,11B-TETRAHYDRO-7-OXA-5-AZA-BENZO[C]FLUORENE-6-CARBOXYLIC ACID DERIVATIVES SERVING AS NMDA ANTAGONISTS | GRUENENTHAL GMBH (DE) | 2008-07-23 | — | — | EP | disclosed |