Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.54 |
| ▸ | TSHR | P16473 | 8/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.51 |
| ▸ | HPGD | P15428 | 11/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.50 |
| ▸ | GBA1 | P04062 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MIF | P14174 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4711135 | 0.82 | HSD17B10 (0.58) | HSD17B10TSHRMAPK1SMN1; SMN2MAPT | |
| SCHEMBL4711734 | 0.79 | HSD17B10 (0.55) | HSD17B10TSHRMAPK1SMN1; SMN2MAPT | |
| SCHEMBL8243917 | 0.79 | HSD17B10 (0.55) | HSD17B10TSHRMAPK1SMN1; SMN2MAPT | |
| SCHEMBL4710577 | 0.79 | ALDH1A1 (0.53) | HSD17B10TSHRMAPK1SMN1; SMN2MAPT | |
| SCHEMBL4759771 | 0.75 | HSD17B10 (0.51) | HSD17B10TSHRMAPK1SMN1; SMN2MAPT | |
| SCHEMBL4712785 | 0.75 | HSD17B10 (0.59) | HSD17B10TSHRMAPK1SMN1; SMN2MAPT | |
| SCHEMBL9165831 | 0.75 | PDK1 (0.37) | MAPK1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL4711791 | 0.75 | KDM4E (0.63) | HSD17B10TSHRMAPK1SMN1; SMN2MAPT | |
| SCHEMBL4390839 | 0.72 | ALDH1A1 (0.78) | HSD17B10TSHRMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4709405 | 0.72 | ALDH1A1 (0.67) | HSD17B10TSHRMAPK1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957475-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007045876-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-04-26 | — | — | WO | disclosed |