Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | STS | P08842 | 15/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.59 |
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.59 |
| ▸ | CA4 | P22748 | 1/20 | 0.59 |
| ▸ | CA6 | P23280 | 1/20 | 0.59 |
| ▸ | CA5A | P35218 | 1/20 | 0.59 |
| ▸ | CA7 | P43166 | 1/20 | 0.59 |
| ▸ | CA9 | Q16790 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.59 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14514741 | 0.89 | MEN1 (0.52) | MEN1KMT2ASTSKDM4EALDH1A1 | |
| SCHEMBL14514724 | 0.86 | ALDH1A1 (0.50) | MEN1KMT2ASTSKDM4EALDH1A1 | |
| SCHEMBL4709135 | 0.84 | MEN1 (0.48) | MEN1KMT2ASTSKDM4EALDH1A1 | |
| SCHEMBL4709560 | 0.83 | MEN1 (0.47) | MEN1KMT2ASTSKDM4EALDH1A1 | |
| SCHEMBL13921229 | 0.80 | KMT2A (0.44) | MEN1KMT2ASTSKDM4EALDH1A1 | |
| SCHEMBL13921226 | 0.79 | KMT2A (0.43) | MEN1KMT2ASTSKDM4EALDH1A1 | |
| SCHEMBL29853363 | 0.79 | MAPT (0.63) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL26781086 | 0.79 | MAPT (0.63) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL5114194 | 0.78 | MEN1 (0.43) | MEN1KMT2ASTSKDM4EALDH1A1 | |
| SCHEMBL8124201 | 0.78 | CA12 (0.45) | MEN1KMT2ASTSKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812417-B1 | NOVEL 2H-CHROMENE DERIVATIVES AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-10-29 | — | — | EP | disclosed |
| EP-1812417-A1 | NOVEL 2H-CHROMENE DERIVATIVES AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-08-01 | — | — | EP | disclosed |
| US-20060166933-A1 | Novel 2H-chromene derivatives as selective estrogen receptor modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-27 | — | — | US | disclosed |
| WO-2006055694-A1 | NOVEL 2H-CHROMENE DERIVATIVES AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060166933-A1 | Novel 2H-chromene derivatives as selective estrogen receptor modulators | ESR2, ESR1, GPER1 | MEN1 4456/4885KMT2A 1599/4885STS 1873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.