Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 12/20 | 0.74 |
| ▸ | RARG | P13631 | 12/20 | 0.74 |
| ▸ | RARA | P10276 | 11/20 | 0.74 |
| ▸ | RXRA | P19793 | 14/20 | 0.47 |
| ▸ | RXRB | P28702 | 5/20 | 0.47 |
| ▸ | RXRG | P48443 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4712935 | 1.00 | RARB (0.74) | RARBRARGRARARXRARXRB | |
| SCHEMBL4711988 | 0.89 | RARG (0.58) | RARBRARGRARARXRARXRB | |
| SCHEMBL4711986 | 0.89 | RARG (0.58) | RARBRARGRARARXRARXRB | |
| SCHEMBL14159976 | 0.88 | RARB (0.57) | RARBRARGRARAMEN1RECQL | |
| SCHEMBL14159923 | 0.86 | RARA (0.55) | RARBRARGRARARXRARXRB | |
| SCHEMBL10841477 | 0.85 | RARB (1.00) | RARBRARGRARARXRARXRB | |
| SCHEMBL156460 | 0.85 | RARB (1.00) | RARBRARGRARARXRARXRB | |
| Hydrochloric Acid SCHEMBL4432609 | 0.84 | RARB (0.97) | RARBRARGRARARXRARXRB | |
| SCHEMBL4760186 | 0.82 | RARG (0.50) | RARBRARGRARARXRARXRB | |
| SCHEMBL4760188 | 0.79 | RARG (0.47) | RARBRARGRARARXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1935869-A1 | Retinoids for the treatment of emphysema | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-25 | — | — | EP | disclosed |
| EP-1935869-A1 | Retinoids for the treatment of emphysema | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-25 | — | — | EP | disclosed |
| US-6777418-B2 | FOR TREATING OR PREVENTING EMPHYSEMA, CANCER AND DERMATOLOGICAL DISORDERS | SYNTEX (U.S.A.) LLC | 2004-08-17 | — | — | US | disclosed |