Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 5/20 | 0.57 |
| ▸ | RARG | P13631 | 5/20 | 0.57 |
| ▸ | RARA | P10276 | 4/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | VDR | P11473 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14159923 | 0.89 | RARA (0.55) | RARBRARGRARAVDRLMNA | |
| SCHEMBL4712934 | 0.88 | RARB (0.74) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL4712935 | 0.88 | RARB (0.74) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL2594345 | 0.86 | RARB (0.75) | RARBRARGRARAPTPN1VDR | |
| SCHEMBL10844561 | 0.86 | RARB (0.64) | RARBRARGRARAPTPN1VDR | |
| SCHEMBL4666958 | 0.86 | RARB (0.75) | RARBRARGRARAPTPN1VDR | |
| SCHEMBL10844563 | 0.86 | RARB (0.64) | RARBRARGRARAPTPN1VDR | |
| SCHEMBL14159916 | 0.81 | RARB (0.49) | RARBRARGRARAPTPN1VDR | |
| SCHEMBL14159838 | 0.81 | RARB (0.49) | RARBRARGRARAPTPN1VDR | |
| SCHEMBL4759945 | 0.81 | RARB (0.49) | RARBRARGRARAPTPN1VDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1935869-A1 | Retinoids for the treatment of emphysema | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-25 | — | — | EP | disclosed |