Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | KMO | O15229 | 5/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.35 |
| ▸ | TACR3 | P29371 | 2/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14188402 | 0.91 | CDC7 (0.61) | CDC7KMOPIK3C3TACR3MAPKAPK2 | |
| Trifluoroacetic Acid SCHEMBL4716136 | 0.87 | CDC7 (0.52) | CDC7KMOPIK3C3PSEN1PSEN2 | |
| Trifluoroacetic Acid SCHEMBL4997521 | 0.87 | CDC7 (0.55) | CDC7PIK3C3MAPKAPK2PIM1PIM2 | |
| Trifluoroacetic Acid SCHEMBL5000129 | 0.85 | CDC7 (0.53) | CDC7PIK3C3MAPKAPK2PIM1PIM2 | |
| Trifluoroacetic Acid SCHEMBL4999615 | 0.85 | CDC7 (0.55) | CDC7PIK3C3MAPKAPK2PIM1PIM2 | |
| Trifluoroacetic Acid SCHEMBL4790707 | 0.85 | CDC7 (0.52) | CDC7PIK3C3MAPKAPK2 | |
| Trifluoroacetic Acid SCHEMBL4715188 | 0.85 | CDC7 (0.52) | CDC7KDM2BKDM4C | |
| Trifluoroacetic Acid SCHEMBL4996147 | 0.85 | CDC7 (0.52) | CDC7PIK3C3KDM4CMAPKAPK2PIM1 | |
| Trifluoroacetic Acid SCHEMBL4996962 | 0.83 | CDC7 (0.47) | CDC7KMOPIK3C3MAPKAPK2PIM1 | |
| Trifluoroacetic Acid SCHEMBL4712543 | 0.82 | CDC7 (0.48) | CDC7PIK3C3MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080113971-A1 | PYRAZOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | HANAU CATHLEEN E | 2008-05-15 | — | — | US | disclosed |
| EP-1572682-A4 | ACYCLIC PYRAZOLE COMPOUNDS | PHARMACIA CORP (US) | 2008-01-23 | — | — | EP | disclosed |
| EP-1572682-A2 | ACYCLIC PYRAZOLE COMPOUNDS | Pharmacia Corporation (US) | 2005-09-14 | — | — | EP | disclosed |
| US-20040152739-A1 | Acyclic pyrazole compounds for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-08-05 | — | — | US | disclosed |
| WO-2004058176-A2 | ACYCLIC PYRAZOLE COMPOUNDS | PHARMACIA CORPORATION (US) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113971-A1 | PYRAZOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | MKNK2, MAPKAPK2, MAP3K2 | CDC7 487/4885KMO 444/4885TTR 4246/4885 |
| US-20040152739-A1 | Acyclic pyrazole compounds for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MAPKAPK2, MAP3K2, MAP4K2 | CDC7 331/4885KMO 445/4885TTR 4668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.