Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.55 |
| ▸ | GRM5 | P41594 | 13/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12884290 | 0.82 | TTR (0.62) | TTRGRM5KCNH2CA12CA9 | |
| SCHEMBL5778843 | 0.81 | GRM5 (0.62) | TTRGRM5KCNH2CA12CA9 | |
| SCHEMBL2808776 | 0.81 | TTR (0.62) | TTRGRM5KCNH2CA12CA1 | |
| SCHEMBL2808633 | 0.81 | TTR (0.55) | TTRGRM5KCNH2 | |
| SCHEMBL2807844 | 0.81 | TTR (0.55) | TTRGRM5KCNH2 | |
| SCHEMBL12884286 | 0.79 | GRM5 (0.65) | TTRGRM5KCNH2CA12CA9 | |
| SCHEMBL15877006 | 0.77 | GRM5 (0.62) | TTRGRM5KCNH2CA12CA9 | |
| SCHEMBL20593924 | 0.76 | GRM5 (0.56) | TTRGRM5KCNH2CA12CA9 | |
| SCHEMBL30108246 | 0.76 | GRM5 (0.56) | TTRGRM5KCNH2CA12CA9 | |
| SCHEMBL9302636 | 0.75 | CA12 (0.62) | GRM5SLC6A2CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | claimed |
| EP-0998459-A2 | PYRIDINE DERIVATIVES | Novartis AG (CH) | 2000-05-10 | — | — | EP | claimed |
| WO-1999002497-A2 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 1999-01-21 | — | — | WO | claimed |
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | disclosed |
| US-6656957-B1 | Marked and selective modulating, especially antagonistic, action at human metabotropic glutamate receptors (mGluRs); treatment of disorders such as epilepsy, cerebral ischemias, especially acute ischemias, spasticity etc. | NOVARTIS AG (CH) | 2003-12-02 | — | — | US | disclosed |