Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.50 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4713250 | 1.00 | MEN1 (0.50) | MEN1KMT2ANPC1HSP90AA1AGTR1 | |
| SCHEMBL4711231 | 0.77 | FGFR1 (0.41) | MEN1KMT2ANPC1HSP90AA1AGTR1 | |
| SCHEMBL4711228 | 0.77 | FGFR1 (0.41) | MEN1KMT2ANPC1HSP90AA1AGTR1 | |
| SCHEMBL4710680 | 0.76 | NPC1 (0.49) | MEN1KMT2ANPC1HSP90AA1AGTR1 | |
| SCHEMBL4710683 | 0.76 | NPC1 (0.49) | MEN1KMT2ANPC1HSP90AA1AGTR1 | |
| SCHEMBL4710678 | 0.74 | MAPT (0.48) | MEN1KMT2ANPC1HSP90AA1AGTR1 | |
| SCHEMBL4710682 | 0.74 | MAPT (0.48) | MEN1KMT2ANPC1HSP90AA1AGTR1 | |
| SCHEMBL4761685 | 0.72 | KMT2A (0.59) | MEN1KMT2ANPC1HSP90AA1AGTR1 | |
| SCHEMBL4761687 | 0.72 | KMT2A (0.59) | MEN1KMT2ANPC1HSP90AA1AGTR1 | |
| SCHEMBL29021958 | 0.69 | NPC1 (0.66) | MEN1KMT2ANPC1HSP90AA1AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | claimed |
| EP-0998459-A2 | PYRIDINE DERIVATIVES | Novartis AG (CH) | 2000-05-10 | — | — | EP | claimed |
| WO-1999002497-A2 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 1999-01-21 | — | — | WO | claimed |
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | disclosed |