Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 7/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4711231 | 1.00 | FGFR1 (0.41) | FGFR1FGFR3RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL7267902 | 0.84 | FGFR1 (0.44) | FGFR1FGFR3RAB9ASMN1; SMN2MAPT | |
| SCHEMBL4710062 | 0.83 | FGFR1 (0.40) | FGFR1FGFR3RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL4710063 | 0.83 | FGFR1 (0.40) | FGFR1FGFR3RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL4714523 | 0.81 | MEN1 (0.47) | FGFR1FGFR3RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL4714522 | 0.81 | MEN1 (0.47) | FGFR1FGFR3RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL7262198 | 0.78 | FGFR1 (0.44) | FGFR1FGFR3RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL7262186 | 0.78 | CYP1A2 (0.43) | FGFR1FGFR3RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL4713250 | 0.77 | MEN1 (0.50) | RAB9ASMN1; SMN2CYP1A2CYP1A1CYP1B1 | |
| SCHEMBL4713253 | 0.77 | MEN1 (0.50) | RAB9ASMN1; SMN2CYP1A2CYP1A1CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | claimed |
| EP-0998459-A2 | PYRIDINE DERIVATIVES | Novartis AG (CH) | 2000-05-10 | — | — | EP | claimed |
| WO-1999002497-A2 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 1999-01-21 | — | — | WO | claimed |
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | disclosed |