Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.49 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 3/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.43 |
| ▸ | GABRD | O14764 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4710680 | 1.00 | NPC1 (0.49) | NPC1MEN1KMT2AHSP90AA1AGTR1 | |
| SCHEMBL4710682 | 0.83 | MAPT (0.48) | NPC1MEN1KMT2AHSP90AA1AGTR1 | |
| SCHEMBL4710678 | 0.83 | MAPT (0.48) | NPC1MEN1KMT2AHSP90AA1AGTR1 | |
| SCHEMBL4713060 | 0.78 | RAB9A (0.46) | NPC1MEN1KMT2AHSP90AA1ALDH1A1 | |
| SCHEMBL4713064 | 0.78 | RAB9A (0.46) | NPC1MEN1KMT2AHSP90AA1ALDH1A1 | |
| SCHEMBL4713250 | 0.76 | MEN1 (0.50) | NPC1MEN1KMT2AHSP90AA1AGTR1 | |
| SCHEMBL4713253 | 0.76 | MEN1 (0.50) | NPC1MEN1KMT2AHSP90AA1AGTR1 | |
| SCHEMBL10496414 | 0.75 | ALDH1A1 (0.61) | NPC1MEN1KMT2AHSP90AA1ALDH1A1 | |
| SCHEMBL9798058 | 0.75 | ALDH1A1 (0.61) | NPC1MEN1KMT2AHSP90AA1ALDH1A1 | |
| SCHEMBL3901458 | 0.72 | GABRP (0.56) | MEN1KMT2AALDH1A1SMN1; SMN2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | claimed |
| EP-0998459-A2 | PYRIDINE DERIVATIVES | Novartis AG (CH) | 2000-05-10 | — | — | EP | claimed |
| WO-1999002497-A2 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 1999-01-21 | — | — | WO | claimed |
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | disclosed |
| CN-1203060-C | Pyridine derivatives, compositions and uses thereof | NOVARTIS AG (CH) | 2005-05-25 | — | — | CN | disclosed |
| US-6656957-B1 | Marked and selective modulating, especially antagonistic, action at human metabotropic glutamate receptors (mGluRs); treatment of disorders such as epilepsy, cerebral ischemias, especially acute ischemias, spasticity etc. | NOVARTIS AG (CH) | 2003-12-02 | — | — | US | disclosed |
| CN-1262676-A | Pyridine derivatives | NOVARTIS AG (CH) | 2000-08-09 | — | — | CN | disclosed |