Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | GRM5 | P41594 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | THPO | P40225 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4713335 | 1.00 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2AKDM4ENPC1 | |
| Pyridine SCHEMBL27565602 | 0.92 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL4711881 | 0.89 | ALDH1A1 (0.58) | ALDH1A1MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL4712492 | 0.88 | ALDH1A1 (0.51) | ALDH1A1MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL4712491 | 0.88 | ALDH1A1 (0.51) | ALDH1A1MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL5865031 | 0.82 | GRM4 (0.61) | MEN1KMT2AGRM4NPSR1PKM | |
| SCHEMBL5865029 | 0.82 | GRM4 (0.61) | MEN1KMT2AGRM4NPSR1PKM | |
| SCHEMBL18002675 | 0.82 | NFE2L2 (0.53) | MEN1KMT2ANPSR1PKMNFE2L2 | |
| Hydrochloric Acid SCHEMBL5865413 | 0.81 | GRM4 (0.59) | MEN1KMT2AGRM4NPSR1PKM | |
| Hydrochloric Acid SCHEMBL5865415 | 0.81 | GRM4 (0.59) | MEN1KMT2AGRM4NPSR1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | claimed |
| EP-0998459-A2 | PYRIDINE DERIVATIVES | Novartis AG (CH) | 2000-05-10 | — | — | EP | claimed |
| WO-1999002497-A2 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 1999-01-21 | — | — | WO | claimed |
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | disclosed |
| CN-1203060-C | Pyridine derivatives, compositions and uses thereof | NOVARTIS AG (CH) | 2005-05-25 | — | — | CN | disclosed |
| CN-1262676-A | Pyridine derivatives | NOVARTIS AG (CH) | 2000-08-09 | — | — | CN | disclosed |