Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KYNU | Q16719 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | CTSK | P43235 | 4/20 | 0.47 |
| ▸ | CTSS | P25774 | 3/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | MIF | P14174 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | CPN1 | P15169 | 1/20 | 0.44 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2185631 | 0.83 | PSEN1 (0.50) | CTSKCTSSCTSLPSEN1PSEN2 | |
| SCHEMBL1820061 | 0.83 | KYNU (0.51) | KYNUHIF1ALMNAKDM4EADRB1 | |
| SCHEMBL29687004 | 0.83 | KYNU (0.51) | KYNUHIF1ALMNAKDM4EADRB1 | |
| SCHEMBL2848810 | 0.83 | ESR1 (0.44) | KYNUHIF1ALMNAKDM4ECTSK | |
| SCHEMBL1716112 | 0.82 | CYP2C19 (0.53) | LMNACTSKCTSSCTSLPSEN1 | |
| SCHEMBL4310706 | 0.82 | CTSK (0.67) | CTSKCTSSCTSLPSEN1PSEN2 | |
| SCHEMBL4039064 | 0.82 | CTSK (0.67) | CTSKCTSSCTSLPSEN1PSEN2 | |
| SCHEMBL4309572 | 0.82 | CTSK (0.67) | CTSKCTSSCTSLPSEN1PSEN2 | |
| SCHEMBL1492705 | 0.82 | CTSK (0.46) | CTSKCTSSCTSLPSEN1PSEN2 | |
| SCHEMBL4957164 | 0.81 | KYNU (0.53) | KYNUHIF1ALMNAKDM4EADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1248612-B1 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2008-02-27 | — | — | EP | claimed |
| WO-2001049288-A9 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | MERCK FROSST CANADA INC (CA) | 2001-10-25 | — | — | WO | disclosed |