Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 3/20 | 0.48 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | PRKCA | P17252 | 1/20 | 0.48 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.48 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.46 |
| ▸ | GSK3B | P49841 | 3/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 2/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propionic Acid SCHEMBL4161183 | 0.93 | JAK2 (0.47) | PIK3C3SYKCAMK2DABL1EGFR | |
| Propionic Acid SCHEMBL4161864 | 0.81 | ABL1 (0.37) | SYKABL1CAMKK2GSK3BMAPK8 | |
| SCHEMBL3244486 | 0.81 | CAMK2D (0.51) | PIK3C3SYKCAMK2DABL1EGFR | |
| Propionic Acid SCHEMBL4169954 | 0.80 | AURKA (0.43) | SYKMAPK8JAK2IKBKBSPHK1 | |
| Propionic Acid SCHEMBL4160185 | 0.79 | PDPK1 (0.47) | MAPK8EIF2AK2SPHK1 | |
| Propionic Acid SCHEMBL4160216 | 0.77 | AURKA (0.41) | SYKMAPK8JAK2IKBKBSPHK1 | |
| SCHEMBL4161175 | 0.77 | CAMK2D (0.45) | PIK3C3SYKCAMK2DABL1EGFR | |
| SCHEMBL3244692 | 0.75 | SPHK1 (0.43) | PIK3C3SYKCAMK2DCAMKK2GSK3B | |
| SCHEMBL3254744 | 0.74 | JAK2 (0.44) | PIK3C3SYKCAMK2DCAMKK2GSK3B | |
| Propionic Acid SCHEMBL4157712 | 0.73 | CDK2 (0.41) | SYKCAMKK2GSK3BJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | disclosed |