Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 4/20 | 0.51 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.51 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 2/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.45 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 3/20 | 0.44 |
| ▸ | BCR | P11274 | 2/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3244692 | 0.88 | SPHK1 (0.43) | CAMK2DCAMKK2CAMKK1MAPK8PIK3CG | |
| SCHEMBL3245637 | 0.88 | DDX3X (0.41) | CAMK2DCAMKK2CAMKK1MAPK8PIK3CG | |
| SCHEMBL3245619 | 0.88 | AURKA (0.47) | CAMK2DCAMKK2CAMKK1MAPK8PIK3CG | |
| SCHEMBL3245517 | 0.85 | PDPK1 (0.46) | CAMKK2CAMKK1MAPK8PIK3CGGSK3B | |
| SCHEMBL4161175 | 0.85 | CAMK2D (0.45) | CAMK2DCAMKK2CAMKK1MAPK8PIK3CG | |
| SCHEMBL3249380 | 0.82 | CAMKK2 (0.46) | CAMKK2MAPK8GSK3BJAK2JAK3 | |
| SCHEMBL3254744 | 0.82 | JAK2 (0.44) | CAMK2DCAMKK2CAMKK1MAPK8PIK3CG | |
| SCHEMBL3244502 | 0.81 | CSNK2A1 (0.49) | GSK3B | |
| SCHEMBL3251264 | 0.81 | PDPK1 (0.43) | — | |
| SCHEMBL4713573 | 0.81 | PIK3C3 (0.49) | CAMK2DCAMKK2CAMKK1MAPK8PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |