Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | PTPN7 | P35236 | 6/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 6/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 2/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 2/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL623982 | 0.82 | PTPN7 (0.42) | NR3C2PTPN7DUSP3CTSSCTSK | |
| SCHEMBL29492591 | 0.82 | PTPN7 (0.42) | NR3C2PTPN7DUSP3CTSSCTSK | |
| SCHEMBL4715187 | 0.80 | MEN1 (0.57) | MEN1KMT2ADAO | |
| SCHEMBL3244152 | 0.78 | TAAR1 (0.53) | NR3C2PTPN7DUSP3ARCYP2D6 | |
| SCHEMBL2600223 | 0.77 | CTSS (0.46) | NR3C2PTPN7DUSP3CTSSCTSK | |
| SCHEMBL27789311 | 0.77 | NR3C2 (0.46) | NR3C2PTPN7DUSP3AREPHX1 | |
| Hydrochloric Acid SCHEMBL3230959 | 0.77 | TAAR1 (0.52) | NR3C2PTPN7DUSP3ARCYP2D6 | |
| SCHEMBL3637053 | 0.77 | NR3C2 (0.49) | NR3C2PTPN7DUSP3AREPHX1 | |
| SCHEMBL10662203 | 0.75 | PTPN7 (0.47) | NR3C2PTPN7DUSP3AREPHX1 | |
| SCHEMBL9103643 | 0.75 | MEN1 (0.52) | MEN1KMT2ACYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1337517-B1 | PYRIMIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 2008-11-26 | — | — | EP | disclosed |